Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/6542
Títulos: Gender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity
Autores/as: Guerra, Borja 
Fuentes, Teresa
Delgado-Guerra, Safira
Guadalupe-Grau, Amelia 
Olmedillas, Hugo
Santana, Alfredo 
Ponce-González, Jesús Gustavo
Dorado, C 
Calbet, José A.L. 
Clasificación UNESCO: 2411 Fisiología humana
Palabras clave: Leptin
Testosterone
Fat
Fecha de publicación: 2008
Resumen: To determine if there is a gender dimorphism in the expression of leptin receptors (OB-R170, OB-R128 and OB-R98) and the protein suppressor of cytokine signaling 3 (SOCS3) in human skeletal muscle, the protein expression of OB-R, perilipin A, SOCS3 and alpha-tubulin was assessed by Western blot in muscle biopsies obtained from the m. vastus lateralis in thirty-four men (age = 27.1+/-6.8 yr) and thirty-three women (age = 26.7+/-6.7 yr). Basal serum insulin concentration and HOMA were similar in both genders. Serum leptin concentration was 3.4 times higher in women compared to men (P<0.05) and this difference remained significant after accounting for the differences in percentage of body fat or soluble leptin receptor. OB-R protein was 41% (OB-R170, P<0.05) and 163% (OB-R128, P<0.05) greater in women than men. There was no relationship between OB-R expression and the serum concentrations of leptin or 17beta-estradiol. In men, muscle OB-R128 protein was inversely related to serum free testosterone. In women, OB-R98 and OB-R128 were inversely related to total serum testosterone concentration, and OB-R128 to serum free testosterone concentration. SOCS3 protein expression was similar in men and women and was not related to OB-R. In women, there was an inverse relationship between the logarithm of free testosterone and SCOS3 protein content in skeletal muscle (r = -0.46, P<0.05). In summary, there is a gender dimorphism in skeletal muscle leptin receptors expression, which can be partly explained by the influence of testosterone. SOCS3 expression in skeletal muscle is not up-regulated in women, despite very high serum leptin concentrations compared to men. The circulating form of the leptin receptor can not be used as a surrogate measure of the amount of leptin receptors expressed in skeletal muscles.
URI: http://hdl.handle.net/10553/6542
DOI: 10.1371/journal.pone.0003466
Aparece en la colección:Artículos

Archivos en este elemento:
Archivo Descripción TamañoFormato 
Gender_Dimorphism_in_Skeletal_Muscle.pdfGender dimorphism in skeletal muscle leptin receptors, serum leptin and insulin sensitivity230,79 kBAdobe PDFObserva/Abre
Muestra el registro completo del elemento

Citas SCOPUSTM   

37
actualizado el 26-nov-2018

Citas de WEB OF SCIENCETM
Citations

36
actualizado el 27-nov-2018

Google ScholarTM

Verifica

Altmetric


Este elemento está sujeto a una licencia Licencia Creative Commons Creative Commons