Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/6537
Títulos: Androgen receptor gene polymorphisms lean mass and performance in young men
Autores/as: Guadalupe-Grau, Amelia 
Rodriguez-Gonzalez, Francisco Germán
Dorado, C 
Olmedillas, Hugo
Fuentes, Teresa
Pérez-Gómez, Jorge
Delgado-Guerra, Safira
Vicente-Rodríguez, Germán
Ara, Ignacio
Arteaga-Ortiz, Rafael 
Guerra, Borja 
Calbet, José A.L. 
Diaz-Chico, Bonifacio 
Clasificación UNESCO: 2411 Fisiología humana
Palabras clave: Testosterone
Exercise
performance
Fecha de publicación: 2009
Resumen: The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGN(n), polyglycine) or its transcriptional activity (CAG(n), polyglutamine). Shorter CAG and/or GGN repeats provide stronger androgen signalling and vice versa. To test the hypothesis that CAG and GGN repeat AR polymorphisms affect muscle mass and various variables of muscular strength phenotype traits, the length of CAG and GGN repeats was determined by PCR and fragment analysis and confirmed by DNA sequencing of selected samples in 282 men (28.6 +/- 7.6 years). Individuals were grouped as CAG short (CAG(S)) if harbouring repeat lengths of <!--= 21 and CAG long (CAG(L)) if CAG -->21. GGN was considered short (GGN(S)) or long (GGN(L)) if GGN <!--= 23 or -->23, respectively. No significant differences in lean body mass or fitness were observed between the CAG(S) and CAG(L) groups, or between GGN(S) and GGN(L) groups, but a trend for a correlation was found for the GGN repeat and lean mass of the extremities (r=-0.11, p=0.06). In summary, the lengths of CAG and GGN repeat of the AR gene do not appear to influence lean mass or fitness in young men.
URI: http://hdl.handle.net/10553/6537
ISSN: 0306-3674
DOI: 10.1136/bjsm.2009.060285
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