Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/6511
Títulos: The lactate paradox revisited in lowlanders during acclimatization to 4100 m and in high-altitude natives
Autores/as: van Hall, Gerrit
Lundby, Carsten
Araoz, M.
Calbet, José A.L. 
Sander, M.
Saltin, Bengt
Clasificación UNESCO: 241106 Fisiología del ejercicio
Palabras clave: Hypoxia
Fecha de publicación: 2009
Resumen: Chronic hypoxia has been proposed to induce a closer coupling in human skeletal muscle between ATP utilization and production in both lowlanders (LN) acclimatizing to high altitude and high-altitude natives (HAN), linked with an improved match between pyruvate availability and its use in mitochondrial respiration. This should result in less lactate being formed during exercise in spite of the hypoxaemia. To test this hypothesis six LN (22-31 years old) were studied during 15 min warm up followed by an incremental bicycle exercise to exhaustion at sea level, during acute hypoxia and after 2 and 8 weeks at 4100 m above sea level (El Alto, Bolivia). In addition, eight HAN (26-37 years old) were studied with a similar exercise protocol at altitude. The leg net lactate release, and the arterial and muscle lactate concentrations were elevated during the exercise in LN in acute hypoxia and remained at this higher level during the acclimatization period. HAN had similar high values; however, at the moment of exhaustion their muscle lactate, ADP and IMP content and Cr/PCr ratio were higher than in LN. In conclusion, sea-level residents in the course of acclimatization to high altitude did not exhibit a reduced capacity for the active muscle to produce lactate. Thus, the lactate paradox concept could not be demonstrated. High-altitude natives from the Andes actually exhibit a higher anaerobic energy production than lowlanders after 8 weeks of acclimatization reflected by an increased muscle lactate accumulation and enhanced adenine nucleotide breakdown.
URI: http://hdl.handle.net/10553/6511
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2008.160846
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