Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/37131
Títulos: Segmentation of elastic fibres in images of vessel wall sections stained with Weigert's resorcin-fuchsin
Autores/as: Hernández-Morera, Pablo 
Travieso-González, Carlos M. 
Castaño González, Irene
Mompeó Corredera, Blanca 
Ortega Santana, Francisco 
Clasificación UNESCO: 2410 Biología humana
Palabras clave: Elastic fibres
Histopathology
Image analysis
Segmentation
Localthreshold
Thickness calculation
Fecha de publicación: 2017
Revistas: Computer Methods and Programs in Biomedicine 
Resumen: Background and objective: The elastic fibres are an essential component of the extracellular matrix in blood vessel walls that allows a long-range of deformability and passive recoil without energy input. The quantitative determination of elastic fibres will provide information on the state of the vascular wall and to determine the role and behaviour of this key structural element in different physiological and pathological vascular processes. Methods: We present a segmentation method to identify and quantify elastic fibres based on a local threshold technique and some morphological characteristics measured on the segmented objects that facilitate the discrimination between elastic fibres and other image components. The morphological characteristics analysed are the thickness and the length of an object. Results: The segmentation method was evaluated using an image database of vein sections stained with Weigert's resorcin-fuchsin. The performance results are based on a ground truth generated manually resulting in values of sensitivity greater than 80\% with the exception in two samples, and specificity values above 90\% for all samples. Medical specialists carried out a visual evaluation where the observations indicate a general agreement on the segmentation results' visual quality, and the consistency between the methodology proposed and the subjective observation of the doctors for the evaluation of pathological changes in vessel wall. Conclusions: The proposed methodology provides more objective measurements than the qualitative methods traditionally used in the histological analysis, with a significant potential for this method to be used as a diagnostic aid for many other vascular pathological conditions and in similar tissues such as skin and mucous membranes.
URI: http://hdl.handle.net/10553/37131
ISSN: 0169-2607
DOI: 10.1016/j.cmpb.2017.02.018
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