Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/37127
Títulos: Antiproliferative activity and apoptosis induction by 3',4 '-dibenzyloxyflavonol on human leukemia cells
Autores/as: Said Quintana, María de Las Mercedes 
Brouard, Ignacio
Quintana, José
Estévez, Francisco 
Clasificación UNESCO: 32 Ciencias médicas
Palabras clave: Apoptosis
Caspases
Cell cycle
Cytotoxicity
Flavonoids
Fecha de publicación: 2017
Revistas: Chemico-Biological Interactions 
Resumen: In this study, we investigated the effects of synthetic 3',4'-dibenzyloxyflavonol on viabilities of eight human tumor cells. It was cytotoxic against leukemia cells (HL-60, U-937, MOLT-3, K-562, NALM-6, Raji), with significant effects against P-glycoprotein-overexpressing K-562/ADR and Bcl-2-overexpressing U-937/ Bcl-2 cells, but had no significant cytotoxic effects against quiescent or proliferating human peripheral blood mononuclear cells. The IC50 value for the leukemia HL-60 cells was 0.8 +/- 0.1 mu M. This indicates a 60-fold greater toxicity than the naturally occurring flavonol quercetin. Synthetic 3',4'-dibenzyloxyflavonol induced S phase cell cycle arrest and was a potent apoptotic inducer in human leukemia cells. Cell death was (i) mediated by the activation and the cleavage of initiator and executioner caspases; (ii) prevented by the pan-caspase inhibitor z-VAD-fmk; (iii) associated with the release of cytochrome c and with the phosphorylation of members of the mitogen activated protein kinases including p38(MAPK), JNK/SAPK and ERK, and (iv) independent of the generation of reactive oxygen species. The synthetic 3',4'-dibenzyloxyflavonol is a potent cytotoxic compound against several human leukemia cells and might be useful in the development of new strategies in the fight against cancer.
URI: http://hdl.handle.net/10553/37127
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2017.02.010
Aparece en la colección:Artículos

Muestra el registro completo del elemento

Citas SCOPUSTM   

5
actualizado el 26-nov-2018

Citas de WEB OF SCIENCETM
Citations

5
actualizado el 27-nov-2018

Vista de página(s)

5
actualizado el 26-nov-2018

Google ScholarTM

Verifica

Altmetric


Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor, con todos los derechos reservados, a menos que se indique lo contrario.