Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/35489
Títulos: The Mediterranean Diet decreases LDL atherogenicity in high cardiovascular risk individuals: a randomized controlled trial
Autores/as: Hernáez, Alvaro
Castañer, O.
Goday, Alberto
Ros, Emilio
Pintó, Xavier
Estruch, Ramón
Salas-Salvadó, Jordi
Corella, Dolores
Arós, Fernando
Serra-Majem, Lluis 
Martínez-González, Miguel Ángel
Fiol, Miquel
Lapetra, José
de la Torre, R.
López-Sabater, M. Carmen
Fitó, Montse
Clasificación UNESCO: 3206 Ciencias de la nutrición
Palabras clave: LDL cytotoxicity
LDL oxidation
LDL size
Low density lipoproteins
Mediterranean diet
Fecha de publicación: 2017
Revistas: Molecular Nutrition and Food Research 
Resumen: Scope: Traditional Mediterranean diet (TMD) protects against cardiovascular disease through several mechanisms such as decreasing LDL cholesterol levels. However, evidence regarding TMD effects on LDL atherogenic traits (resistance against oxidation, size, composition, cytotoxicity) is scarce. Methods and results: We assessed the effects of a 1-year intervention with a TMD on LDL atherogenic traits in a random sub-sample of individuals from the PREDIMED study (N= 210). We compared two TMDs: one enriched with virgin olive oil (TMD-VOO, N = 71) and another with nuts (TMD-Nuts, N = 68), versus a low-fat control diet (N = 71). After the TMD-VOO intervention, LDL resistance against oxidation increased (+6.46%, p = 0.007), the degree of LDL oxidative modifications decreased (-36.3%, p<0.05), estimated LDL particle size augmented (+3.06%, p = 0.021), and LDL particles became cholesterol-rich (+2.41% p = 0.013) relative to the low-fat control diet. LDL lipoproteins became less cytotoxic for macrophages only relative to baseline (-13.4%, p = 0.019). No significant effects of the TMD-Nuts intervention on LDL traits were observed versus the control diet. Conclusion: Adherence to a TMD, particularly when enriched with virgin olive oil, decreased LDL atherogenicity in high cardiovascular risk individuals. The development of less atherogenic LDLs could contribute to explaining some of the cardioprotective benefits of this dietary pattern.
URI: http://hdl.handle.net/10553/35489
ISSN: 1613-4125
DOI: 10.1002/mnfr.201601015
Aparece en la colección:Artículos

Muestra el registro completo del elemento

Citas SCOPUSTM   

11
actualizado el 26-nov-2018

Citas de WEB OF SCIENCETM
Citations

6
actualizado el 27-nov-2018

Vista de página(s)

3
actualizado el 26-nov-2018

Google ScholarTM

Verifica

Altmetric


Los elementos en ULPGC accedaCRIS están protegidos por derechos de autor, con todos los derechos reservados, a menos que se indique lo contrario.