Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/35332
Títulos: Allele imputation and haplotype determination from databases composed of nuclear families
Autores/as: Medina-Rodríguez, Nathan
Santana-del-Pino, Angelo 
Clasificación UNESCO: 2409 Genética
1209 Estadística
Palabras clave: MAP
Association
Genome
HLA
Fecha de publicación: 2017
Revistas: R Journal 
Resumen: The alleHap package is designed for imputing genetic missing data and reconstruct nonrecombinant haplotypes from pedigree databases in a deterministic way. When genotypes of related individuals are available in a number of linked genetic markers, the program starts by identifying haplotypes compatible with the observed genotypes in those markers without missing values. If haplotypes are identified in parents or offspring, missing alleles can be imputed in subjects containing missing values. Several scenarios are analyzed: family completely genotyped, children partially genotyped and parents completely genotyped, children fully genotyped and parents containing entirely or partially missing genotypes, and founders and their offspring both only partially genotyped. The alleHap package also has a function to simulate pedigrees including all these scenarios. This article describes in detail how our package works for the desired applications, including illustrated explanations and easily reproducible examples.
URI: http://hdl.handle.net/10553/35332
ISSN: 2073-4859
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