Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/18969
Títulos: The Influence of Estrogens on the Biological and Therapeutic Actions of Growth Hormone in the Liver
Autores/as: Mirecki Garrido, Mercedes de
Guerra, Borja 
Mateos-Díaz, Carlos
Jímenez-Monzón, Roberto
Diaz-Chico, Bonifacio 
Díaz Chico, Juan Carlos 
Fernandez-Perez, Leandro 
Clasificación UNESCO: 320101 Oncología
Palabras clave: growth hormone
17β-estradiol
liver
growth
metabolism
STAT5
Fecha de publicación: 2012
Resumen: GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway
GH is main regulator of body growth and composition, somatic development, intermediate metabolism and gender-dependent dimorphism in mammals. The liver is a direct target of estrogens because it expresses estrogen receptors which are connected with development, lipid metabolism and insulin sensitivity, hepatic carcinogenesis, protection from drug-induced toxicity and fertility. In addition, estrogens can modulate GH actions in liver by acting centrally, regulating pituitary GH secretion, and, peripherally, by modulating GHR-JAK2-STAT5 signalling pathway
URI: http://hdl.handle.net/10553/18969
DOI: 10.3390/ph5070758
Derechos: by-nc-nd
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