Utiliza este identificador para citar o vincular este elemento: http://hdl.handle.net/10553/12132
Títulos: Assessment of the presence of pharmaceutical compounds in seawater samples from coastal area of Gran Canaria Island (Spain)
Autores/as: Afonso-Olivares, Cristina 
Torres-Padrón, M. E. 
Sosa-Ferrera Z. 
Santana-Rodríguez, José Juan 
Clasificación UNESCO: 2301 química analítica
Palabras clave: Pharmaceutical compounds
SPE
LC-MS/MS
Seawater
Outfall
Fecha de publicación: 2013
Resumen: This study presents the evaluation of seven pharmaceutical compounds belonging to different commonly used therapeutic classes in seawater samples from coastal areas of Gran Canaria Island. The target compounds include atenolol (antihypertensive), acetaminophen (analgesic), norfloxacin and ciprofloxacin (antibiotics), carbamazepine (antiepileptic) and ketoprofen and diclofenac (anti-inflammatory). Solid phase extraction (SPE) was used for the extraction and preconcentration of the samples, and liquid chromatography tandem mass spectrometry (LC-MS/MS) was used for the determination of the compounds. Under optimal conditions, the recoveries obtained were in the range of 78.3% to 98.2%, and the relative standard deviations were less than 11.8%. The detection and quantification limits of the method were in the ranges of 0.1–2.8 and 0.3–9.3 ng·L−1, respectively. The developed method was applied to evaluate the presence of these pharmaceutical compounds in seawater from four outfalls in Gran Canaria Island (Spain) during one year. Ciprofloxacin and norfloxacin were found in a large number of samples in a concentration range of 9.0–3551.7 ng·L−1. Low levels of diclofenac, acetaminophen and ketoprofen were found sporadically.
URI: http://hdl.handle.net/10553/12132
DOI: 10.3390/antibiotics2020274
Derechos: by-nc-nd
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